Table 2.
Comparison between type III IgG4-LAD and angioimmunoblastic T-cell lymphoma (AITL)
| Type III IgG4-LAD | AITL | |
|---|---|---|
| Presentation | Often systemic lymphadenopathy, but no constitutional symptoms | Systemic lymphadenopathy and marked constitutional symptoms |
| Serum LDH | Normal or mildly increased | Markedly increased |
| Architecture | Distorted, but at least partially preserved | Markedly distorted or effaced |
| Vascularity | Increased | Markedly increased with arborization |
| Clear cells | Usually inconspicuous | Often abundant |
| FDC meshwork | Normal size and morphology | Markedly expanded and distorted |
| PD1+/CD10+ cells | Limited to the germinal centers | Present in the atypical clear cells |
| EBV | Negative | Scattered, positive in immunoblasts |
| TRG@PCR | Polyclonal | Monoclonal |
| Prognosis | Benign clinical course; good response to steroid therapy | Poor |