Table 3.
Comparison between type IV IgG4-LAD and IgG4-negative PTGC
| Type IV IgG4-LAD | Usual IgG4 Negative PTGC | |
|---|---|---|
| Age/gender | Mostly middle-aged or elderly male | Younger age, slight male predominance |
| Locations | Localized or systemic, axillary, mediastinal, intraabdominal | Often isolated, mostly cervical, axillary or inguinal |
| Duration | Persistent | Recurs in 20% cases |
| Low-power features | Similar with PTGCs | Similar with PTGCs |
| Plasma cells in germinal center | Markedly increased | Usually not increased |
| Interfollicular eosinophils | Often increased | May or may not be increased |
| IgG4, IgG4/IgG | Markedly increased | Not increased |
| Serum IgG4 | Mostly raised | Not raised |
| Extranodal IgG4-RD | Often present | No |
| Risk | Systemic IgG4-related disease | NLPHL |