Table 5.
Univariate and multivariate survival analyses of clinicopathological characteristics and CD68 macrophage with overall survival for Kazakh esophageal carcinoma (ESCC)
| Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| HR | 95% CI | P | HR | 95% CI | P | |||
| Age (≥58 y) | 0.611 | 0.359 | 1.041 | 0.070 | 0.467 | 0.259 | 0.841 | 0.074 |
| Sex (female) | 1.202 | 0.674 | 2.144 | 0.533 | 1.313 | 0.686 | 2.512 | 0.411 |
| Differentiation (moderate/poor) | 1.536/1.022 | 0.758/0.526 | 3.112/1.985 | 0.234/0.948 | 2.513/1.432 | 1.115/0.658 | 5.661/3.117 | 0.026/0.365 |
| L/N metastasis (positive) | 1.956 | 1.139 | 3.360 | 0.015* | 1.108 | 0.423 | 2.902 | 0.834 |
| Clinical stage (III + IV) | 2.093 | 1.226 | 3.575 | 0.007* | 1.894 | 0.746 | 4.812 | 0.179 |
| Depth of invasion (T1-T2/T3-T4) | 1.001 | 0.579 | 1.733 | 0.996 | 0.216 | 0.343 | 1.273 | 0.661 |
| Tumor location (Middle/Lower) | 2.283/1.292 | 0.282/0.606 | 18.51/2.753 | 0.439/0.507 | 6.661/1.271 | 0.619/0.560 | 71.632/2.888 | 0.118/0.566 |
| CD68+ macrophages counts in tumor nest (High) | 1.898 | 1.060 | 3.399 | 0.031* | 1.849 | 0.870 | 3.929 | 0.110 |
| CD68+ macrophages counts in tumor stroma (High) | 1.544 | 0.899 | 2.652 | 0.115 | 0.900 | 0.448 | 1.808 | 0.767 |
Note: L/N, lymph node; CI, confidence interval; HR, hazard radio.
*
Significant difference that 95% CI was not including 1.