Table 1.

Correlations between clinicopathologic factors and BDNF in patients with intrahepatic cholangiocarcinoma

Clinicopathologic parameters		n	BDNF		P*
			Low	High
Age (years)	<65	70	46	24	0.811
	≥65	26	16	10
Sex	Male	50	31	19	0.671
	Female	46	31	15
Tumor size (cm)	<5 cm	31	19	12	0.655
	≥5 cm	65	43	22
Differentiation	Good	27	18	9	0.571
	Moderate	47	32	15
	Poor	22	12	10
T stage	T1+2	71	48	23	0.336
	T3+4	25	14	11
N stage	N0	67	47	20	0.086
	N1	29	15	14
M stage	M0	92	61	31	0.126
	M1	4	1	3
TNM stage	I+II	50	36	14	0.236
	III+IV	46	26	20
HBV	Negative	85	53	32	0.318
	Positive	11	9	2
Microvascular invasion	Negative	78	49	29	0.588
	Positive	18	13	5
Cirrhosis	Negative	79	51	28	0.612
	Positive	17	11	6
Intraneural invasion	Negative	85	59	26	0.007
	Positive	11	3	8
VEGF	Low	47	33	14	0.291
	High	49	29	20

^*Means calculated by Fisher test.

Abbreviations: BDNF = brain-derived neurotrophic factor, vascular endothelial growth factor = VEGF.