Table 2.
Univariate analysis of clinicopathologic parameters in patients with intrahepatic cholangiocarcinoma
| Clinicopathologic parameters | 5-year survival % | P* | |
|---|---|---|---|
| Age (years) | <65 | 42.3 | 0.940 |
| ≥65 | 59.2 | ||
| Sex | Male | 43.0 | 0.184 |
| Female | 46.5 | ||
| Tumor size (cm) | <5 cm | 60.7 | 0.082 |
| ≥5 cm | 36.3 | ||
| Differentiation | Good | 42.0 | 0.446 |
| Moderate | 39.6 | ||
| Poor | 55.5 | ||
| T stage | T1+2 | 51.2 | 0.362 |
| T3+4 | 28.9 | ||
| N stage | N0 | 55.5 | P<0.001 |
| N1 | 13.0 | ||
| M stage | M0 | 45.5 | 0.256 |
| M1 | 25.0 | ||
| TNM stage | I+II | 61.0 | 0.008 |
| III+IV | 27.6 | ||
| HBV | Negative | 44.0 | 0.821 |
| Positive | 57.3 | ||
| Microvascular invasion | Negative | 45.1 | 0.633 |
| Positive | 45.8 | ||
| Cirrhosis | Negative | 42.7 | 0.889 |
| Positive | 57.8 | ||
| Intraneural invasion | Negative | 44.3 | 0.743 |
| Positive | 46.2 | ||
| BDNF | Low | 56.4 | 0.006 |
| High | 25.4 | ||
| VEGF | Low | 59.5 | 0.022 |
| High | 20.4 | ||
*
Means calculated by log-rank test.
Abbreviations: BDNF = brain-derived neurotrophic factor, vascular endothelial growth factor = VEGF.