A. Pedigree of the family affected with AD1. Family members are identified by generations and number. Squares indicate male family members; circles, female members; a closed symbol, the affected member; open symbols, unaffected members; arrow, proband. B. Sequencing result of the TPM2 mutation. Sequence chromatogram indicates a heterozygous mutation (c.463G>A; p.A155T). C. Phenotypes of the part patients. III: 1 had arthrogryposes of 4/5 fingers, III: 3 had arthrogryposes of 2-5 fingers, I: 2 had arthrogryposes of 5th fingers.