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Enforced expression of SIRT6 rescues INS-1 cells from miR-802-induced apoptosis. (A) Western blot analysis of SIRT6 protein levels in INS-1 cells transfected with indicated constructs. Numbers indicate fold change in SIRT6 protein levels. (B) INS-1 cells transfected with indicated constructs and tested for apoptosis 48 h after transfection. (C) Measurement of ROS production in INS-1 cells treated as in (A). *P < 0.05.
