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. 2017 Nov 1;10(11):11288–11299.

Figure 6.

Figure 6

CCL4 promoted angiogenesis by upregulating VEGF-A and pSTAT3. AN3CA and HEC-1B cells were treated with CCL4 (30, 60, 100 μg/ml) or pretreated with the antibody of VEGF-A followed by the application of CCL4 (100 μg/ml). A: The protein expression level of pSTAT3 was detected by Western blot in treated AN3CA cells (*P < 0.05, ***P < 0.001). B: The protein expression level of pSTAT3 was detected by Western blot in treated HEC-1B cells (*P < 0.05, ***P < 0.001). C: The protein expression level of STAT3 was detected by Western blot in treated AN3CA cells. D: The protein expression level of STAT3 was detected by Western blot in treated HEC-1B cells. E: The underlying mechanism of CCL4 induced growth of EC cells.