Table 2.
Univariate and multivariate analyses of prognostic factors predicting the overall survival of CRC patients
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
|
|
||||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Serum miR-193b | ||||||
| Low vs high | 2.643 | 1.425-4.309 | 0.013 | 2.498 | 1.381-4.140 | 0.021 |
| Gender | ||||||
| Male vs female | 1.210 | 0.887-1.831 | 0.318 | |||
| Age | ||||||
| ≥60 vs <60 | 1.294 | 0.913-1.927 | 0.283 | |||
| Tumor size (cm) | ||||||
| ≥5 vs <5 | 1.519 | 0.944-2.415 | 0.192 | |||
| Depth of invasion | ||||||
| T3/T4 vs T1/T2 | 1.435 | 0.932-2.207 | 0.215 | |||
| LN metastasis | ||||||
| Yes vs no | 1.711 | 0.991-2.853 | 0.056 | |||
| Distant metastasis | ||||||
| Yes vs no | 1.683 | 0.984-2.720 | 0.072 | |||
| TNM stage | ||||||
| III-IV vs I-II | 3.120 | 1.941-5.752 | 0.006 | 3.418 | 1.861-6.346 | 0.005 |
| Grade | ||||||
| III vs I-II | 1.921 | 1.080-3.282 | 0.043 | 1.747 | 0.990-3.050 | 0.053 |