Table 4.

Enriched regulated (KEGG) biological pathways in primary aldosteronism

Pathway	Size	Nes	Nom p-val	FDR q-val
Ribosome	88	1.9619	0.0000	0.0000
Oxidative_phosphorylation	117	1.8973	0.0000	0.0000
Proteasome	46	1.8277	0.0000	0.0027
Metabolism_of_xenobiotics_by_cytochrome_p450	70	1.7441	0.0000	0.0198
Cardiac_muscle_contraction	73	1.6957	0.0021	0.0363
Parkinsons_disease	114	1.6879	0.0000	0.0335
Drug_metabolism_cytochrome_p450	72	1.6741	0.0000	0.0364
Olfactory_transduction	386	1.6561	0.0000	0.0418
Tyrosine_metabolism	42	1.5888	0.0040	0.0808
Glutathione_metabolism	50	1.5768	0.0040	0.0843
Neuroactive_ligand_receptor_interaction	271	1.5416	0.0000	0.1109
Type_i_diabetes_mellitus	43	1.5294	0.0103	0.1167
Long_term_depression	70	1.4925	0.0039	0.1583
Histidine_metabolism	28	1.4906	0.0239	0.1497
Prion_diseases	35	1.4563	0.0279	0.1924
Huntingtons_disease	173	1.4525	0.0000	0.1869
Glycine_serine_and_threonine_metabolism	31	1.4483	0.0367	0.1825
Pathogenic_escherichia_coli_infection	56	1.4373	0.0111	0.1923
Autoimmune_thyroid_disease	52	1.4060	0.0268	0.2384
Graft_versus_host_disease	40	1.4035	0.0397	0.2316
Dilated_cardiomyopathy	90	1.3973	0.0141	0.2321
Retinol_metabolism	64	1.3915	0.0273	0.2299
Complement_and_coagulation_cascades	69	1.3895	0.0204	0.2139
Bladder_cancer	42	1.3883	0.0412	0.2074
Hematopoietic_cell_lineage	87	1.3826	0.0108	0.2090
Drug_metabolism_other_enzymes	51	1.3672	0.0448	0.2192
Arginine_and_proline_metabolism	53	1.3617	0.0453	0.2205
Alzheimers_disease	157	1.3439	0.0147	0.2340
Hypertrophic_cardiomyopathy_hcm	83	1.3361	0.0270	0.2262
Glycolysis_gluconeogenesis	61	1.3302	0.0467	0.2305
Mapk_signaling_pathway	265	1.2885	0.0000	0.2754
Chemokine_signaling_pathway	189	1.2875	0.0169	0.2703
Cell_adhesion_molecules_cams	133	1.2819	0.0343	0.2687
Calcium_signaling_pathway	176	1.2666	0.0183	0.2741
Cytokine_cytokine_receptor_interaction	261	1.2600	0.0108	0.2634