Emodin suppressed the expression of invasion-related proteins through down regulating Notch1. A and B: mRNA and protein level of VEGF, VEGFR2, Jagged1 and MMP-2 were inhibited in emdoin treated groups (n=3). Data were shown as mean ± S.D., *P<0.05, **P<0.01 (compared with negative controls); #P<0.05, ##P<0.01 (compared with Notch1 groups).