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. 2017 Sep 1;10(9):9213–9222.

Figure 6.

Figure 6

miR-128 over-expression inhibited cell proliferation and induced cell apoptosis in human thyroid cancer cells through CXCR4/RhoA signaling pathway. After cells were transfected with miR-128 mimics for 24 and 48 h, miR-218 expression was measured by RT-PCR (B). After CXCR4/RhoA signaling pathway was blocked using AMD-3100, protein expression of CXCR4 was tested by Western blot (A). After cells were treated with miR-128 mimics, AMD-3100 or miR-128 mimic plus AMD-3100, cell proliferation (C), the apoptotic rate (D) and mRNA expression of PPARγ, C/EBPα, Caspase-3 and Caspase-9 (E) were demonstrated. Three individual experiments were performed and each treatment had five replicates. Results were presented as means ± SD. *P<0.05 or **P<0.01 compared with control.