Inhibition of miR-181a re-sensitizes resistant cells to cisplatin through BAX upregulation. (A) PC3 cisplatin resistant cells were transfected with control or a miR-181a inhibitor. After 48 hours, the expression of miR-181a or (B) BAX was determined and shown. (C) PC3 cisplatin resistant cells were transfected with control or a miR-181a inhibitor, after 48 hours, cells were treated with cisplatin at 0, 10, 20, 40 or 80 μM for 72 hours, cell viability was measured. *, P < 0.05; ***, P < 0.001.