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. 2017 Dec 1;10(12):11461–11470.

Figure 3.

Figure 3

PDCD6 is a direct target of miR-124. A. Wild-type or mutant miR-124 target sequences in the human PDCD6 3’-UTR. B. Luciferase activity assays were carried out using a luciferase reporter with wild-type (wt) or mutant (mt) human PDCD6 3’-UTRs after co-transfection with miR-124 mimics or inhibitor into HEK293 cells. The mt 3’-UTR level increased significantly compared with the wt 3’-UTR. The bar graph shows the mean ± SD of results from three independent transfection experiments. *P<0.05. C. PDCD6 expression in NPC cells treated as described were detected using qRT-PCR. ANOVA and the Student’s t test were used to determine the statistical significance of the differences among groups. *P<0.05.