Table 1.

Stoichiometric equation of carbon conservative pathways described in Figures 1–5, and their calculated thermodynamic value^*.

Pathway name	Equation	ΔrG′O* (KJ/mole)
NOG	Glucose + 1 ATP + 3 CoaSH -> 3 acetyl-CoA + 1 ADP + 1 Pi	−193.6
PGB	Glucose + 4 NAD(P)+ + 2 CoASH -> 2 acetyl-CoA + 2CO2 + 4 NAD(P)H + 4 H+	−204
EP-Bifido	Glucose + 2 NAD(P)+ + 1 ATP + 2.5 CoASH + H2O -> 2.5 acetyl-CoA + 1 CO2 + 1 ADP + 1 Pi + 2 NAD(P)H + 2H+	−180.6
rGS	Glucose + 1 NAD+ + 1 ADP + 1 QH2 + 1 Pi + 3 CoASH -> 3 acetyl-CoA + 1 NADH + 1 H+ + 1 ATP + 1 Quinone	−229
MCG	Glucose + 1 ADP + 1 Pi + 3 CoaSH -> 3 acetyl-CoA + 1 ATP + H2O	−193.6
Glycoptimus	Glucose + 1 ATP + 3 NAD+ + H2O -> 3 glycolic acid + 1 ADP + 1 Pi + 3 NADH + 3 H+	−139.6
MOG	Glucose + 2 ${\text{HCO}}_3^{-}$+ 3 ATP + 3 H2O -> 2 glyoxylate + 2 acetate + 3ADP +3 Pi	−233
Mser	Methanol + CO2 + 2H2O + 4 ATP + CoASH + NADP(H) + H+ -> Acetyl-CoA + 4ADP + 4 Pi + NAD(P)+	−153
HOB	Tetrahydrofolate+ 2 NAD(P)H + ${\text{HCo}}_3^{-}+$ 4H2O + 3ATP -> 5′-10-methylene tetrahydrofolate + 3 ADP + 3 Pi + 2 NAD(P)+	−63.5

^*Gibbs energy value of the reaction was calculated using eQuilibrator (at http://equilibrator.weizmann.ac.il/).