Figure 2.

Kill curves and TTP for standard and PaMZ regimens. As shown in (a), (b) and (c), there was no difference in the kill curves of the standard regimen versus the PaMZ regimen against intracellular, log-phase growth and semi-dormant M. tuberculosis, respectively. Both regimens took virtually the same time to sterilize the HFS-TB. However, by TTP, the PaMZ regimen took longer to kill the intracellular M. tuberculosis compared with the standard regimen (d), was similar to the standard therapy against the log-phase growth M. tuberculosis (e) and failed to sterilize the systems in the experiment with the semi-dormant M. tuberculosis (f). Thus, in the HFS-TB, PaMZ was not superior to the current standard regimen.