Figure 4.

Time to extinction on the PaMZ regimen. Observed HFS-TB model results versus patient-predicted outcomes for the PaMZ regimen. (a) Intracellular and extracellular bacteria in log-phase growth are represented by orange circles and bacteria in the semi-dormant state are represented by grey circles. The separate bacterial subpopulations are explained with the red and black model fitted lines, respectively. (b) The HFS-model data-constrained trajectories are then translated to show the patient-associated bacteria–time kinetics during therapy with the PaMZ regimen. (c) The proportion of patients that will get cured (i.e. achieve bacterial extinction) is low with 3 months or 4 months duration of therapy, and would be virtually identical to the standard regimen if administered for 6 months duration. 3 M, 3 months; 4 M, 4 months; 6 M, 6 months. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC.