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. 2019 Dec 5;19(2):913–922. doi: 10.3892/etm.2019.8285

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effect of heparin on activated coagulation parameters in an LPS-induced sepsis rat model. (A) F1+2 and (C) TAT were determined using an ELISA at 0.5, 2 and 6 h after LPS injection, respectively. Effect of UFH or NAH on (B) F1+2 and (D) TAT in the plasma at 2 and 6 h after LPS injection. Data are presented as mean ± standard deviation. There were 6 animals in each group at 0.5, 2 and 6 h. *P<0.05 vs. the control group; ^#P<0.05 vs. the LPS group. The F1+2 data were analyzed using a Kruskal-Wallis test along with Bonferroni correction. The TAT data were analyzed using a one-way analysis of variance followed by a Student-Newman-Keuls test for multiple group comparisons. LPS, lipopolysaccharide; F1+2, prothrombin fragment 1+2; TAT, thrombin-antithrombin complex; UFH, unfractionated heparin; NAH, N-acetylheparin.