Table II.
Effect of UFH or NAH on APTT, PT and FIB level in LPS-induced sepsis rat model.
| Group | APTT, sec | PT, sec | FIB levels, g/l |
|---|---|---|---|
| Control | 20.5±1.4 | 15.6±0.4 | 2.5±0.11 |
| LPS 6h | 60.9±5.8a | 18.3±1.9 | 1.3±0.23a |
| UFH + LPS | 49.6±4.6b,c | 18.3±1.0 | 1.9±0.34b |
| NAH + LPS | 55.6±5.9 | 18.7±1.2 | 1.7±0.24b |
Data are presented as mean ± standard deviation. There were 6 animals in each group.
a
P<0.05 vs. the control group
b
P<0.05 vs. the LPS 6 h group
c
P<0.05 vs. the NAH + LPS group. A Kruskal-Wallis test along with Bonferroni correction was used for data that were nonnormally distributed. LPS, lipopolysaccharide; UFH, Unfractionated heparin; NAH, N-acetylheparin; APTT, activated partial thromboplastin time; PT, prothrombin time; FIB, fibrinogen.