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. 2020 Jan 10;11:359. doi: 10.3389/fnagi.2019.00359

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Copyright © 2020 Lykhmus, Kalashnyk, Uspenska and Skok.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Episodic memory [Discrimination Index (DI)] of mice studied in the NOR test. (A) Mice were injected with lipopolysaccharide (LPS) and treated with PNU282 either immediately or 7 days after (groups 2–4, Table 1) or with PNU120 or PNU120+PNU282 immediately after LPS (groups 5–6); (B) mice were injected with LPS and treated with nicotine (group 7), or treated with PNU282 2 months after LPS injection (group 9). Each point on the curve corresponds to Mean ± SD, n = 5. **p < 0.005; ***p < 0.0005 compared to Day 0. For LPS 2m, Day 0 corresponds to 2 months after LPS injection.