Table 2.

Normalized content of nicotinic acetylcholine receptors (nAChR) subunits in the brain non-mitochondria fraction of the mice listed in Table 1.

Groups/nAChR subunits	α3	α4	α7	α9	β2	β4
Ctrl	100 ± 3	100 ± 7	100 ± 7	100 ± 8	101 ± 4	100 ± 13
LPS	106 ± 11	83 ± 9	101 ± 5	145 ± 22*	86 ± 7*	189 ± 13***
LPS+PNU282	127 ± 14##	112 ± 7###	131 ± 9###	132 ± 9	117 ± 7##	187 ± 24
LPS+PNU120	136 ± 13###	113 ± 7###	134 ± 12###	129 ± 15	101 ± 3##	226 ± 10###
LPS+PNU120/282	182 ± 25###	111 ± 9###	119 ± 12#	120 ± 11	117 ± 8###	200 ± 16
LPS+Nic	101 ± 12	68 ± 6#	94 ± 9	111 ± 10	108 ± 7##	176 ± 21
LPS 2m	126 ± 10*	77 ± 9*	79 ± 7**	142 ± 12**	87 ± 18	194 ± 11***
LPS 2m+PNU282	99 ± 15&	67 ± 9	101 ± 9&	107 ± 11&	90 ± 8	174 ± 13

Data are shown as Mean ± SD, the data of non-treated mice (Ctrl) being taken as 100%. *p < 0.05; **p < 0.005; ***p < 0.0005 compared to Ctrl; ^#p < 0.05; ^##p < 0.005; ^###p < 0.0005 compared to LPS; and ^&p < 0.05; ^&&p < 0.005 compared to LPS 2m; n = 5. The row LPS+PNU282 combines data obtained for groups 3 and 4 (Table 1: PNU282 given either simultaneously with or 7 days after LPS). Significantly changed values are marked in Bold (in electron version, red marks increase, blue marks decrease).