Figure 9.

Demonstration of aerosol deposition pattern and dose-dependency of inhibition of bacterial growth by allicin (allicin-susceptible E. coli MegaX DH10B™ T1R cells transformed with empty pRU1097 vector). (A) Water or (B-D, 0.25, 0.5 and 1.0 mM, respectively) the allicin aerosol was aspirated through the lung model at 11 l/min for 20 min. Inhibition of bacterial growth was seen at 0.5 mM allicin aerosol mainly at the bronchial surfaces around the carinal branch points. At 1 mM allicin aerosol inhibition was complete over all the bronchial surfaces.