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. 2019 Dec 5;19(2):999–1005. doi: 10.3892/etm.2019.8294

Figure 1.

Figure 1.

LINC00858 is upregulated in RB tissues and cell lines, while knockout of LINC00858 inhibits RB cell proliferation. (A) Compared with that in normal paracancerous tissues, the relative expression of LINC00858 was significantly upregulated in RB tissues. (B) Increased relative LINC00858 expression was detected in RB cell lines (SO-RB50, Y79, HXO-RB44 and WERI-Rb1) when compared with that in a normal retinal epithelial cell line (ARPE-19). (C) SO-RB50 and Y79 cells of the si-LINC00858 group had a significantly lower relative LINC00858 expression than cells of the si-NC group. (D) Cell Counting Kit-8 assay showed that at 48 and 72 h of culture, SO-RB50 cells of the si-LINC00858 group had obviously lower optical density values at 450 nm than cells of the si-NC group. (E) Cell Counting Kit-8 assay showed that at 48 and 72 h of culture, Y79 cells in the si-LINC00858 group exhibited lower optical density values at 450 nm compared with cells in the si-NC group. *P<0.05. RB, retinoblastoma; LINC00858, long intergenic non-protein coding RNA 858; si-LINC00858, small interfering RNA targeting LINC00858; si-NC, scrambled control.