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. 2020 Jan 10;9:1470. doi: 10.3389/fonc.2019.01470

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Copyright © 2020 van der Heijden, Essers, de Jong, de Roest, Sanduleanu, Verhagen, Hamming-Vrieze, Hoebers, Lambin, Bartelink, Leemans, Verheij, Brakenhoff, van den Brekel and Vens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of individual biological factors for locoregional control. (A) Results of individual bootstrap analysis (see methods) including important clinical factors. The fraction of randomized cohorts with a significant association with locoregional control is shown for each cut-off and biological marker. Markers are ordered by the magnitude of the maximum fraction of significant Cox proportional hazard tests at the best cut-off. The best cutoff is indicated with dotted red lines. (B) For each marker, the cohort was split into a high and low group at the best cutoff determined in A. Hazard ratios for recurrences and corresponding p-values were obtained with a multivariate Cox proportional hazard analysis using the same variables as those used to determine the cutoff.