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. 2020 Jan 10;9:1470. doi: 10.3389/fonc.2019.01470

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Copyright © 2020 van der Heijden, Essers, de Jong, de Roest, Sanduleanu, Verhagen, Hamming-Vrieze, Hoebers, Lambin, Bartelink, Leemans, Verheij, Brakenhoff, van den Brekel and Vens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relevance of biological markers for HNSCC chemo-radiotherapy outcomes. Forest plots comparing individual biological markers across different outcome endpoints are shown. Hazard Ratios for locoregional recurrences, distant metastasis, disease progression and death are from multivariate Cox proportional hazard analyses of the dichotomized cohorts using bootstrap analysis defined cut-offs for all outcomes analyzed in this study. For each marker the “low” score or low expression group was used as reference. Each individual model contained the same clinical variables as those used to determine the cut-off. Only the biological markers are shown.