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. 2020 Jan 10;9:1470. doi: 10.3389/fonc.2019.01470

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Copyright © 2020 van der Heijden, Essers, de Jong, de Roest, Sanduleanu, Verhagen, Hamming-Vrieze, Hoebers, Lambin, Bartelink, Leemans, Verheij, Brakenhoff, van den Brekel and Vens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative role of biological markers in combined analyses. Forest plots with results from full multivariate Cox Proportional Hazards models are shown. The model was generated using a backward selection procedure. The most frequent level was used as the reference level for this analysis. A Cox proportional hazard model was fit that included all biological markers and clinical variables. Then, each variable was individually eliminated from the model and improvements in model performance were assessed. This process was repeated with the best performing models until the removal of variables did no longer improve the models. Hazard ratios for locoregional recurrences (A) and distant metastasis (B) as determined by the final model are shown.