Table 1.
NKL homeobox gene expression in normal B-cell development and B-cell lymphomas.
| Gene | HSC | LMPP | CLP | DN | DP | BCP | NB | GCB | MB | PC | HL | FL | DLBCL | HCL | MCL | SMZL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HHEX | ||||||||||||||||
| HLX | ||||||||||||||||
| MSX1 | ||||||||||||||||
| NANOG | ||||||||||||||||
| NKX2-3 | ||||||||||||||||
| NKX3-1 | ||||||||||||||||
| NKX6-3 | ||||||||||||||||
| TLX2 | ||||||||||||||||
| VENTX | ||||||||||||||||
| BARX2 | ||||||||||||||||
| DLX1 | ||||||||||||||||
| EMX2 | ||||||||||||||||
| NKX2-1 | ||||||||||||||||
| NKX2-2 | ||||||||||||||||
| NKX3-2 |
Physiologically expressed genes are indicated in red, deregulated gene activities detected in patients are indicated in orange. BCP: B-cell progenitor, CLP: common lymphoid progenitor, DLBCL: diffuse large B-cell lymphoma, DN: double negative, DP: double positive, FL: follicular lymphoma, GCB: germinal center B-cell, HCL: hairy cell leukemia, HL: Hodgkin lymphoma, HSC: hematopoietic stem cell, LMPP: lymphoid primed multipotent progenitor, MB: memory B-cell, NB: naive B-cell, PC: plasma cell, MCL: mantle cell lymphoma, SMZL: splenic marginal zone lymphoma. This table is modified as described previously [39].