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. 2019 Dec 13;11(12):2015. doi: 10.3390/cancers11122015
IMWG International Myeloma Working Group
MRD minimal residual disease
NGF next-generation flow
NGS next-generation sequencing
FLC free light chain
M-protein myeloma protein
FCM flow cytometry
SUVmax maximum standardized uptake value
MFC multiparameter flow cytometry
FDG Fluorodeoxyglucose
PET/CT Positron emission tomography/computed tomography
N number
TTP time to progression
y year
NR not reached
CA chromosomal abnormalities
PCs plasma cells
BMPCs bone marrow PCs
HR hazard ratio
FLCr free light chain ratio
FISH fluorescence in situ hybridization
Pts patients
V bortezomib
R, Len lenalidomide
d, dex dexamethasone
T thalidomide
FU follow-up
PFS progression-free survival
OS overall survival
G grade
P p-value
MM multiple myeloma
K carfilzomib
CRAB hypercalcemia, renal failure, anemia, and bone lesions
SMM smoldering MM
ORR overall response rate
Dara daratumumab
ASCT autologous stem-cell transplantation
Y years
NA not available
iv intravenous
D day
AE adverse event
sc subcutaneous
p.o. orally
G-CSF granulocyte colony-stimulating factor
Obs. observation
TE Transplant-eligible
NTE non-transplant-eligible
NDMM newly diagnosed multiple myeloma
C cyclophosphamide
PD progressive disease
MR minimal response
PR partial response
VGPR very good PR
CR complete response
nCR near CR
sCR stringent CR
CHF congestive heart failure
SPMs second primary malignancies
MRD neg MRD negative/negativity
M, Mel melphalan
Mel200 melphalan at 200 mg/m2
Bu busulfan
p prednisone
Ixa ixazomib
SAEs serious AEs
TEAEs treatment-emergent AEs
GIT gastrointestinal toxicity
QW given every week
Q2W given every two weeks
Q4W given every 4 weeks
CI confidence interval
ISS International Staging System
R-ISS Revised ISS
LDH lactate dehydrogenase
EMD extramedullary disease
CPC circulating plasma cells
mAb monoclonal antibody
PI proteasome inhibitor
IMiDs immunomodulatory drugs