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. 2019 Dec 6;11(12):1964. doi: 10.3390/cancers11121964

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TOP I enzyme acts as an indicator of esophageal squamous cell carcinoma (ESCC). (A) Quantitation results of Topoisomerase (TOP) I immunohistochemical (IHC) staining on ESCC tissue array. Data was shown in the value of log10 (IOD). **, p < 0.01; ***, p < 0.001 compared to normal tissues. (B) Images of IHC staining on esophageal normal (5 cases), adjacent (15 cases), and cancer (19 cases) tissues, separately (40× and 100× magnification). (C) TOP1 gene expression analysis in esophageal normal tissues and different stage cancer tissues (Data downloaded from TCGA database). *, p < 0.05; ***, p < 0.001 compared to normal tissues. (D) Overall survival time of patients with high or low expression of TOP I gene (data obtained from http://gepia.cancer-pku.cn/). (E) The expression of TOP I in different kinds of ESCC cell lines was evaluated by Western blot assay. β-actin was used as an internal reference control.