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. 2019 Nov 23;11(12):1852. doi: 10.3390/cancers11121852

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic illustration of progesterone receptor isoforms. The progesterone receptor has two distinct isoforms, PR-A and PR-B. PR-B is more transcriptionally active due to the extended N-terminal domain that contains AF3 (unique domain), an activation function unit that allows for an increase in co-binding partners and activity. The isoform PR-A is less transcriptionally active than PR-B and primarily functions in non-genomic pathway activity. Its upregulation is implicated in cancers. Abbreviations: PR, Progesterone receptor; NTD, N-terminal domain; DBD, DNA-binding domain; H, Hinge region; LBD, Ligand-binding domain; C, Variable C-terminus; AF1, Activation function-1; AF2, Activation function-2; AF3, Activation function-3.