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Schematic illustration of abiraterone inhibition. Abiraterone inhibits intratumoral synthesis of cholesterol into active androgens that can weakly bind AR in the context of low ligand availability. Abiraterone acts through the enzymatic inhibition of CYP17A1, which ultimately prevents synthesized androgens from further reduction to a more active state. Abbreviations: ABI, Abiraterone; AD, Androstendione; DHEA, Dehydroepiandrosterone.
