Table 1.
Summary of the clinical features and histologic, immunohistochemical and molecular features of tumors.
| Case | Age at Diagnosis (Months) | Gender (M/F) |
AFP Level (ng/mL) |
Specimen Type | Morphology on Biopsy |
Initial Diagnosis | GPC-3 | Hepatocellular Markers | INI1 | CCCP | Subsequent Diagnosis |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 9 | M | 14.2 | B and R | Small cell | SCUD-HB | − | − | Loss | SMARCB1 del | MRT |
| 2 | 11 | F | 90 | B | Small cell | SCUD-HB | + | − | Loss | SMARCB1 del | MRT |
| 3 | 3 | F | 33.8 | B and R | Rhabdoid | MRT | − | − | Loss | SMARCB1 del | MRT |
| 4 | 12 | F | 69.8 | B and R | Small cell * | SCUD-HB | + | − | Loss | SMARCB1 del | MRT |
| 5 | 10 | M | 13.6 | B | Small cell | SCUD-HB | − | − | Loss | SMARCB1 del | MRT |
| 6 | 24 | M | 3.4 | B and R | Small cell | MRT | − | − | Loss | SMARCB1 del | MRT |
M: male, F: female, B: biopsy, R: resection, AFP: alpha fetoprotein, B: biopsy, R: resection, SCUD-HB: small cell undifferentiated hepatoblastoma, MRT: malignant rhabdoid tumor, GPC-3: glypican-3, Hepatocellular markers: includes Hep-par1 and Arginase immunohistochemistry stains, CCCP: Columbia Combined Cancer Panel, del: deletion; * In Case 4, morphology on resection showed small cell and focal rhabdoid features.