Table 1.
Multivariate analysis of prognostic factors For PFS In MM
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Median PFS (mo) | P | HR | (95% CI) | P | |
| Prognostic factors for entire MM series | |||||
| Age | |||||
| <65 y | 28 | .3 | — | — | — |
| ≥65 y | 36 | ||||
| Cytogenetic profile by FISH | |||||
| Standard-risk | 36 | .07 | — | — | — |
| High-risk | 16 | ||||
| Serum IF | |||||
| Negative | 41 | .001 | — | — | — |
| Positive | 18 | 2.4 | (1.3-4.4) | .004 | |
| BM MRD status by NGF | |||||
| Negative | 46 | <.0001 | — | — | — |
| Positive | 25 | ||||
| PB CTPC status by NGF | |||||
| Negative | 46 | <.0001 | — | — | — |
| Positive | 9 | 5.1 | (2.9-8.9) | <.0001 | |
| Prognostic factors for sCR/CR cases | |||||
| Age | |||||
| <65 y | 50 | .5 | — | — | — |
| ≥65 y | 41 | ||||
| Cytogenetic profile by FISH | |||||
| Standard-risk | 50 | .09 | — | — | — |
| High-risk | 28 | ||||
| BM MRD status by NGF | |||||
| Negative | 50 | <.0001 | — | — | — |
| Positive | 25 | 6.1 | (1.5-24.4) | .01 | |
| PB CTPC status by NGF | |||||
| Negative | 46 | <.0001 | — | — | — |
| Positive | 9 | 7.4 | (3.0-18.2) | <.0001 | |
High-risk cytogenetics was defined as presence at diagnosis of t(4;14); t(11;14); t(14;16); 1q amplification, deletion 13q, and/or deletion 17p. Standard-risk cytogenetics includes all other cases. (Data available in 96/137 cases.)
FISH, fluorescent in situ hybridization; IF, immunofixation.