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. 2020 Jan 10;7:899. doi: 10.3389/fchem.2019.00899

Table 3.

Comparison of existing free online tools to predict ADME-Tox properties of compounds.

Web service Transporters predictions CYP450 predictions Hepatotox. predictions Batch prediction Run time for 1 compound
ProTox-II (Drwal et al., 2014) No No No Yes (max. 100) <5 s
BioZyne (Levatić et al., 2013) P-gp No No Not for free ~5 s
QSAR DB (http://qsar.food.dtu.dk/) No Yes No Yes N.A.
pkCSM (Pires et al., 2015) P-gp Yes Yes Yes (max. 100) <5 s for 30 models
Lazar (Maunz et al., 2013) No No No No ~10 s for 6 models
Vienna LiverTox Workspace P-gp, BSEP, BCRP, MRP2, MRP3, MRP4, OATP1B1, OATP1B3 No Yes Not for free ~30 s for 15 models