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Examples of the four clone seeding scenarios as simulated by El-Kebir et al. [21], showing the direction of clone seeding events that were allowed to occur among tumor sites: (a) monoclonal single-source seeding (mS); (b) polyclonal single-source seeding (pS); (c) polyclonal multisource seeding (pM); (d) polyclonal reseeding (pR).
