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Dual effect of p53 on autophagy. Multiple mechanisms have implicated p53 in the regulation of autophagy with both repressing and promoting effects. Regulation of DRAM, Ulk1, Atg7, and Isg20L1 results in promotion of autophagy, whereas repression of PINK1 results in promotion of mitophagy. Effect on AMPK/mTOR pathway negatively influences autophagy and similar effect has been ascribed to cytoplasmic functions of p53.
