Figure 4.

p53 regulates ferroptosis. Iron-dependent lipid peroxidation, more recently named ferroptosis, has been also implicated in the tumor suppression capabilities of p53. Regulation of System Xc⁻ antiport appears to mediate p53 triggered promotion of ferroptotic cell death. Alternative mechanisms implicate p53 in promoting, but also preventing ferroptosis. This include the control of p21 and SAT1 expression. The relevance of this cell death modality for p53 mediate tumor suppression opens to novel intriguing perspectives.