Figure 3.

FoxO3a re-expression induces pro-apoptotic factors and down-regulates proteins involved in cell cycle regulation and GF signaling in TamR cells. (A) IPA reveals the direct FoxO3a downstream targets in TamR BC cells according to the Ingenuity Knowledge Database. The arrows indicate the predicted relationship, as reported in the upper left panel. The color intensity is related to the level of expression. (B–D) Proteins involved in the regulation of cell cycle (B), apoptosis (C) and GF signaling (D) that result modified of at least ±three-fold change by the active FoxO3a expression in TamR BC cells. For each protein, the symbol, the common name (Description), the data bank identification number (ID) and the fold-change expression in TamR/TetOn-AAA cells vs. TamR/TetOn-V cells are reported in the panels.