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. 2019 Nov 25;11(12):1858. doi: 10.3390/cancers11121858

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Kaplan–Meier analysis: FoxO3a expression is a positive prognostic factor in Luminal A BC patients. Relapse-free survival (RFS) and distant metastasis free survival (DMFS) were evaluated in a cohort of Luminal A sub-type patients treated with Tam (Endoc. Ther.: Tam) [RFS - 561 patients (A), DMFS - 469 patients (B)] and treated with unspecified endocrine therapeutics (Endoc. Ther.: Include) [RFS - 681 patients (C), DMFS - 471 patients (D)]. Luminal A patients not receiving endocrine therapeutics (Endoc. Ther.: No) have been also analyzed [RFS - 630 patients (E), DMFS - 327 patients (F)]. K–M analysis was performed regardless of a specific chemotherapeutic treatments (Chemoth.: any). K–M are plotted for high (above median, in red) and low (below median, in black) FoxO3a gene expression. Biased and outlier array data were excluded from the analysis. Hazard-ratios were calculated, at the best auto-selected cut-off, and p-values were calculated using the logrank test and plotted in R.