Skip to main content
. 2019 Nov 29;11(12):1903. doi: 10.3390/cancers11121903

Figure 3.

Figure 3

WISP-1 stimulates the EMT process via the integrin αvβ3 receptor in oral squamous cell carcinoma (OSCC) cells. (A,B) SCC4 cells were pretreated with Arg–Gly–Asp (RGD) (100 nM) or Arg–Ala–Asp (RAD) (100 nM) for 30 min, then stimulated with WISP-1 for 24 h. E-cadherin expression was examined by IF and qPCR assays. (C) Cells were pretreated with RGD or RAD for 30 min then stimulated with WISP-1 for 24 h, and cell migration was examined by the wound healing assay. Results are expressed as the mean ± SEM. * p < 0.05 compared with controls; # p < 0.05 compared with the WISP-1-treated group.