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. 2019 Dec 14;11(12):2023. doi: 10.3390/cancers11122023

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Identification of molecular subtypes of HCC using TCGA data based on the DEGS in the tumor that were also associated with OS from the univariate analysis. (A). The non-negative factorization (NMF) consensus plot for TCGA identified two distinct HCC subtypes: Cluster1 and Cluster2. (B). Histogram showing that Cluster2 (C2) patients had a higher proportion of female patients, more patients with a late stage tumor, and more death events compared to Cluster1(C1). (C). Log-rank tests showed that Cluster2 patients had significantly worse five-year OS, DSS, DFI, and PFI (p < 0.05).