Table 2.
Expression of ATG4B and clinicopathologic outcomes in patients with OSCC.
| Variable | % | OSCC (n = 428) | % | BMSCC (n = 179) | % | TSCC (n = 249) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Median | p Value | Mean ± SD | Median | p Value | Mean ± SD | Median | p Value | ||||
| Sex | ||||||||||||
| Female | 7.9 | 170.76 ± 49.89 | 190.00 | 0.642 * | 2.2 | 179.38 ± 32.04 | 192.50 | 0.662 * | 12.0 | 169.61 ± 52.10 | 190.00 | 0.744 * |
| Male | 92.1 | 166.27 ± 54.25 | 180.00 | 97.8 | 165.99 ± 60.84 | 180.00 | 88.0 | 166.50 ± 48.49 | 175.00 | |||
| Age, y | ||||||||||||
| ≤40 | 15.4 | 165.61 ± 51.38 | 175.00 | 0.166 † | 13.4 | 183.44 ± 57.10 | 180.00 | 0.105 † | 16.9 | 155.42 ± 45.43 | 152.50 | 0.212 † |
| 41–50 | 31.8 | 165.19 ± 56.47 | 170.00 | 30.7 | 158.09 ± 64.01 | 150.00 | 32.5 | 170.01 ± 50.57 | 180.00 | |||
| 51–60 | 29.0 | 160.64 ± 52.92 | 180.00 | 30.2 | 156.76 ± 56.35 | 180.00 | 28.1 | 163.63 ± 50.33 | 177.50 | |||
| >60 | 23.8 | 176.50 ± 52.48 | 185.00 | 25.7 | 178.32 ± 59.83 | 185.00 | 22.5 | 175.00 ± 46.08 | 185.00 | |||
| Subsites | ||||||||||||
| Buccal | 41.8 | 166.28 ± 60.33 | 180.00 | 0.911 * | 100.0 | 166.28 ± 60.33 | 180.00 | |||||
| Tongue | 58.2 | 166.88 ± 48.84 | 180.00 | 100.0 | 166.88 ± 48.84 | 180.00 | ||||||
| Cell differentiation | ||||||||||||
| Well | 17.8 | 164.97 ± 61.05 | 177.50 | 0.558 † | 27.4 | 165.71 ± 63.12 | 180.00 | 0.988 † | 10.8 | 163.61 ± 58.24 | 175.00 | 0.287 † |
| Moderate | 76.2 | 166.15 ± 51.71 | 180.00 | 67.6 | 166.69 ± 60.39 | 180.00 | 82.3 | 165.82 ± 45.98 | 180.00 | |||
| Poor | 6.1 | 177.56 ± 59.18 | 185.00 | 5.0 | 163.89 ± 48.67 | 185.00 | 6.8 | 184.80 ± 64.24 | 195.00 | |||
| AJCC pathological stage | ||||||||||||
| I | 31.8 | 165.66 ± 52.14 | 180.00 | 0.803 † | 35.2 | 168.06 ± 54.54 | 180.00 | 0.806 † | 29.3 | 163.60 ± 50.26 | 180.00 | 0.567 † |
| II | 33.4 | 164.73 ± 52.08 | 175.00 | 26.3 | 165.64 ± 64.73 | 180.00 | 38.6 | 164.29 ± 45.00 | 170.00 | |||
| III | 15.2 | 172.51 ± 60.25 | 180.00 | 10.6 | 176.32 ± 67.70 | 180.00 | 18.5 | 170.94 ± 57.63 | 180.00 | |||
| IV | 19.6 | 166.88 ± 55.11 | 180.00 | 27.9 | 160.85 ± 61.40 | 177.50 | 13.7 | 175.74 ± 43.67 | 190.00 | |||
| T classification | ||||||||||||
| T1 | 33.9 | 164.98 ± 51.80 | 180.00 | 0.389 † | 38.0 | 165.22 ± 54.59 | 177.50 | 0.368 † | 30.9 | 164.77 ± 49.58 | 180.00 | 0.518 † |
| T2 | 43.7 | 171.19 ± 55.78 | 180.00 | 38.0 | 175.00 ± 66.21 | 185.00 | 47.8 | 169.02 ± 49.00 | 175.00 | |||
| T3 | 11.2 | 157.85 ± 46.59 | 175.00 | 6.7 | 154.79 ± 44.19 | 175.00 | 14.5 | 158.87 ± 47.93 | 167.50 | |||
| T4 | 11.2 | 162.60 ± 58.99 | 182.50 | 17.3 | 153.95 ± 63.65 | 170.00 | 6.8 | 178.38 ± 47.10 | 190.00 | |||
| N classification | ||||||||||||
| N0 | 77.3 | 163.40 ± 52.99 a | 175.00 | 0.022 † | 74.9 | 163.34 ± 60.07 | 177.50 | 0.321 † | 79.1 | 163.44 ± 47.74 | 175.00 | 0.049 † |
| N1 | 10.7 | 186.45 ± 60.89 a | 185.00 | 12.3 | 184.32 ± 66.05 | 185.00 | 9.6 | 188.40 ± 57.12 | 183.75 | |||
| N2 | 11.9 | 169.71 ± 49.80 | 180.00 | 12.8 | 166.20 ± 55.66 | 180.00 | 11.2 | 172.59 ± 45.26 | 187.50 | |||
Abbreviations: AJCC, American Joint Committee on Cancer, T: tumor. * p values were estimated by Student’s t-test. † p values were estimated by one-way ANOVA test.