Table 6.
Impact of pATG4B expression levels on DFS according to different demographic and clinicopathologic factors in patients with OSCC.
| Variable | pATG4B | No. (%) | CHR (95% CI) | p Value * | AHR (95% CI) | p Value † |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Female | Low | 12 (35.3) | 1.00 | 1.00 | ||
| High | 22 (64.7) | 1.12 (0.28–4.47) | 0.874 | 0.88 (0.21–3.58) | 0.852 a | |
| Male | Low | 67 (17.0) | 1.00 | 1.00 | ||
| High | 327 (83.0) | 1.33 (0.86–2.06) | 0.206 | 1.44 (0.93–2.24) | 0.105 a | |
| Age, yrs | ||||||
| ≤50 | Low | 38 (18.8) | 1.00 | 1.00 | ||
| High | 164 (81.2) | 1.63 (0.87–3.09) | 0.130 | 1.74 (0.92–3.29) | 0.089 a | |
| >50 | Low | 41 (18.1) | 1.00 | 1.00 | ||
| High | 185 (81.9) | 1.18 (0.68–2.04) | 0.567 | 1.22 (0.70–2.13) | 0.477 a | |
| Cell differentiation | ||||||
| Well | Low | 7 (9.2) | 1.00 | 1.00 | ||
| High | 69 (90.8) | 23.92 (0.04–14170.39) | 0.330 | 540189.98 (0.00) | 0.978 b | |
| Moderate, poor | Low | 72 (20.5) | 1.00 | 1.00 | ||
| High | 280 (79.5) | 1.40 (0.92–2.13) | 0.119 | 1.36 (0.89–2.07) | 0.157 b | |
| AJCC pathological stage | ||||||
| I, II | Low | 57 (20.7) | 1.00 | 1.00 | ||
| High | 222 (79.6) | 1.04 (0.65–1.68) | 0.863 | 1.15 (0.71–1.87) | 0.558 c | |
| III, IV | Low | 22 (14.8) | 1.00 | 1.00 | ||
| High | 127 (85.2) | 2.55 (1.03–6.34) | 0.044 | 2.59 (1.04–6.45) | 0.040 c | |
| T classification | ||||||
| T1, T2 | Low | 64 (19.3) | 1.00 | 1.00 | ||
| High | 268 (80.7) | 1.21 (0.77–1.90) | 0.402 | 1.30 (0.83–2.04) | 0.260 d | |
| T3, T4 | Low | 15 (15.6) | 1.00 | 1.00 | ||
| High | 81 (84.4) | 2.49 (0.77–8.07) | 0.129 | 2.29 (0.70–7.47) | 0.170 d | |
| N classification | ||||||
| N0 | Low | 67 (20.2) | 1.00 | 1.00 | ||
| High | 264 (79.8) | 1.13 (0.72–1.77) | 0.605 | 1.24 (0.79–1.95) | 0.354 e | |
| N1, N2 | Low | 12 (12.4) | 1.00 | 1.00 | ||
| High | 85 (87.6) | 2.69 (0.84–8.64) | 0.097 | 2.59 (0.80–8.32) | 0.112 e | |
| Postoperative RT | ||||||
| No | Low | 57 (18.3) | 1.00 | 1.00 | ||
| High | 254 (81.7) | 1.17 (0.73–1.86) | 0.517 | 1.18 (0.74–1.90) | 0.488 a | |
| Yes | Low | 22 (18.8) | 1.00 | 1.00 | ||
| High | 95 (81.2) | 2.24 (0.89–5.65) | 0.088 | 2.51 (0.99–6.34) | 0.053 a |
Abbreviations: * p values were estimated by Cox regression. † p values were estimated by multivariate Cox regression. a Adjusted for cell differentiation (moderate + poor vs. well) and AJCC pathological stage (stage III + IV vs. stage I + II). b Adjusted for AJCC pathological stage (stage III + IV vs. stage I + II). c Adjusted for cell differentiation (moderate + poor vs. well). d Adjusted for cell differentiation (moderate + poor vs. well) and N classification (N1, N2 vs. N0). e Adjusted for cell differentiation (moderate + poor vs. well) and T classification (T3, T4 vs. T1 + T2).