Table A1.
Impact of pATG4B expression levels on disease-specific survival according to different demographic and clinicopathologic factors in patients with OSCC.
| Variable | pATG4B | No. (%) | CHR (95% CI) | p Value * | AHR (95% CI) | p Value † |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Female | Low | 5 (14.7) | 1.00 | 1.00 | ||
| High | 29 (85.3) | 1.43 (0.18–11.30) | 0.735 | 1.09 (0.13–8.98) | 0.939 a | |
| Male | Low | 39 (9.9) | 1.00 | 1.00 | ||
| High | 355 (90.1) | 1.11 (0.66–1.85) | 0.699 | 1.09 (0.65–1.83) | 0.745 a | |
| Age, yrs | ||||||
| ≤50 | Low | 22 (10.9) | 1.00 | 1.00 | ||
| High | 180 (89.1) | 0.94 (0.49–1.81) | 0.845 | 0.90 (0.47–1.74) | 0.751 a | |
| >50 | Low | 22 (9.7) | 1.00 | 1.00 | ||
| High | 204 (90.3) | 1.38 (0.64–2.98) | 0.417 | 1.27 (0.59–2.76) | 0.544 a | |
| Cell differentiation | ||||||
| Well | Low | 5 (6.6) | 1.00 | 1.00 | ||
| High | 71 (93.4) | 1.16 (0.15–8.74) | 0.887 | 1.88 (0.24–14.68) | 0.548 b | |
| Moderate, poor | Low | 39 (11.1) | 1.00 | 1.00 | ||
| High | 313 (88.9) | 1.21 (0.72–2.03) | 0.466 | 1.05 (0.63–1.77) | 0.846 b | |
| AJCC pathological stage | ||||||
| I, II | Low | 31 (11.1) | 1.00 | 1.00 | ||
| High | 248 (88.9) | 1.33 (0.61–2.89) | 0.471 | 1.48 (0.68–3.23) | 0.321 c | |
| III, IV | Low | 13 (8.7) | 1.00 | 1.00 | ||
| High | 136 (91.3) | 0.88 (0.46–1.70) | 0.705 | 0.83 (0.43–1.60) | 0.580 c | |
| T classification | ||||||
| T1, T2 | Low | 35 (10.5) | 1.00 | 1.00 | ||
| High | 297 (89.5) | 1.18 (0.64–2.20) | 0.600 | 1.11 (0.60–2.08) | 0.737 d | |
| T3, T4 | Low | 9 (9.4) | 1.00 | 1.00 | ||
| High | 87 (90.6) | 1.03 (0.44–2.40) | 0.944 | 0.80 (0.33–1.90) | 0.609 d | |
| N classification | ||||||
| N0 | Low | 38 (11.5) | 1.00 | 1.00 | ||
| High | 293 (88.5) | 1.04 (0.57–1.90) | 0.897 | 1.17 (0.64–2.13) | 0.615 e | |
| N1, N2 | Low | 6 (6.2) | 1.00 | 1.00 | ||
| High | 91 (93.8) | 0.83 (0.33–2.06) | 0.685 | 0.70 (0.27–1.80) | 0.460 e | |
| Postoperative RT | ||||||
| No | Low | 30 (9.6) | 1.00 | 1.00 | ||
| High | 281 (90.4) | 1.20 (0.61–2.37) | 0.603 | 1.07 (0.54–2.13) | 0.846 a | |
| Yes | Low | 14 (12.0) | 1.00 | 1.00 | ||
| High | 103 (88.0) | 1.23 (0.59–2.57) | 0.584 | 1.19 (0.57–2.49) | 0.651 a |
Abbreviations: * p values were estimated by Cox regression. † p values were estimated by multivariate Cox regression. a Adjusted for cell differentiation (moderate + poor vs. well) and AJCC pathological stage (stage III + IV vs stage I + II). b Adjusted for AJCC pathological stage (stage III + IV vs. stage I + II). c Adjusted for cell differentiation (moderate + poor vs. well). d Adjusted for cell differentiation (moderate + poor vs. well) and N classification (N1, N2 vs. N0). e Adjusted for cell differentiation (moderate + poor vs. well) and T classification (T3, T4 vs. T1 + T2).