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. 2019 Dec 9;11(12):1982. doi: 10.3390/cancers11121982

Table 2.

Comparison of IC50 values (μM) of mitoxantrone-free liposomes and mitoxantrone-containing liposomes for all cell lines. Values are averages of three independent measurements with standard deviation.

Liposomal Formulation Cell Line
A375 Hs294T NHDF
IC50 48 h IC50 72 h IC50 48 h IC50 72 h IC50 48 h IC50 72 h
Lip Vit.C 286.5 ± 31 158.37 ± 35 74.92 ± 7.5 43.95 ± 0.3 174.3 ± 7.3 122.06 ± 9
LipAA5 Vit.C 15.4 ± 3 12.63 ± 5 30.43 ± 6.65 0.52 ± 0.03 188.5 ± 20.8 152.93 ± 11
Lip AA10 Vit.C 17 ± 0.3 58.71 ± 7.4 3.54 ± 0.5 1 ± 0.03 23.4 ± 1.5 20.01 ± 0.46
Lip AA15 Vit.C 14.8 ± 0.08 1.78 ± 0.5 1.93 ± 0.5 5.59 ± 1.34 19.57 ± 0.8 19.32 ± 0.93
Lip AA20 Vit.C 17.7 ± 2.1 2.71 ± 0.55 1.7 ± 0.4 0.6 ± 0.04 26.87 ± 3 12.12 ± 2.8
Lip AA40 Vit.C 1.35 ± 0.2 0.93 ± 0.09 1.26 ± 0.07 0.29 ± 0.06 20 ± 1.3 9.1 ± 0.84
Lip AS 240.5 ± 57 99.06 ± 14.2 123.15 ± 7 86.33 ± 6.8 44.5 ± 3.6 6 ± 1.1
Lip AA5 AS 36.1 ± 6 92.37 ± 18.9 109.43 ± 7.7 55.64 ± 9.4 58.36 ± 6.1 5.4 ± 1.3
Lip MIT Vit.C 50.44 ± 4.3 10.58 ± 3 19.52 ± 7.6 10.3 ± 2 41.25 ± 3.21 20.48 ± 4.25
Lip AA5 MIT Vit.C 0.4 ± 0.05 0.24 ± 0.1 1.69 ± 0.3 0.66 ± 0.13 84.04 ± 12.7 44.19 ± 5.7
Lip AA10 MIT Vit.C 0.47 ± 0.02 0.39 ± 0.02 1.88 ± 0.33 0.94 ± 0.04 4.7 ± 0.43 1. ± 0.04
Lip AA15 MIT Vit.C 0.37 ± 0.07 0.39 ± 0.01 0.77 ± 0.05 0.18 ± 0.005 1.5 ± 0.28 0.9 ± 0.006
Lip AA20 MIT Vit.C 0.46 ± 0.03 0.28 ± 0.002 0.18 ± 0.001 0.1 ± 0.007 0.84 ± 0.03 0.23 ± 0.009
Lip AA40 MIT Vit.C 0.04 ± 0.003 0.02 ± 0.002 0.12 ± 0.06 0.07 ± 0.006 0.3 ± 0.02 0.19 ± 0.004
Lip MIT AS 3.87 ± 1.34 32.5 ± 2.51 17.71 ± 1.22 7.11 ± 1.42 40.53 ± 6.2 1.03 ± 0.06
Lip AA5 MIT AS 19.88 ± 4.15 0.6 ± 0.2 16.6 ± 1.7 1.19 ± 0.26 35.92 ± 3.15 1 ± 0.28
MIT 0.22 ± 0.014 0.075 ± 0.001 0.165 ± 0.03 0.13 ± 0.02 0.43 ± 0.02 0.15 ± 0.02