Figure 1.

The human lysine specific demethylase 1 (LSD1) enzyme. (A) The crystal structure of LSD1 is depicted (image from Protein Data Bank, PDB-ID:2H94 [32,33]). (B) The demethylation reaction catalyzed by LSD1. The conversion of demethylated lysine to its monomethylated form is shown. (C) The four isoforms of human LSD1 are shown. The position of the three major domains, Swi3p/Rsc8p/Moira (SWIRM), Tower, and amine-oxidase like AOL (demethylase activity), is illustrated in the smaller, ubiquitous isoform of LSD1. The positions of exons 2a and 8a in the respective isoforms are shown in red.