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. 2019 Nov 20;11(12):1821. doi: 10.3390/cancers11121821

Table 2.

List of clinical trials with LSD1 inhibitors in human solid tumors [127,128,129].

Code Title Status Conditions Interventions
NCT03514407 A Study of INCB059872 in Relapsed or Refractory Ewing Sarcoma Recruiting Relapsed Ewing Sarcoma INCB059872
NCT03600649 Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing Sarcoma Recruiting Ewing Sarcoma SP-2577
EUCTR2018-000469-35 A pilot study to assess the safety, tolerability, dose finding and efficacy ORY-1001 in combination with platinum-etoposide chemotherapy in patients with relapsed, extensive-stage disease small cell lung cancer Ongoing Relapsed, extended-stage disease small cell lung cancer ORY-1001
EUCTR2017-002838-23 Randomized, double-blind, placebo-controlled, 3-arm, 36 weeks parallel-group study to evaluate the safety and tolerability of ORY-2001 in patients with Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis Authorised Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis ORY2001
NCT03505528 An Early Phase Study of Abraxane Combined With Phenelzine Sulfate in Patients With Metastatic or Advanced Breast Cancer Recruiting Metastatic Breast Cancer Nanoparticle albumin-bound paclitaxel| Phenelzine Sulfate
NCT02712905 An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies Recruiting Solid Tumors and Hematologic Malignancy INCB059872| ATRA| azacitidine| nivolumab
NCT03895684 Phase 1 Trial of the LSD1 Inhibitor SP-2577 (Seclidemstat) in Patients With Advanced Solid Tumors Not yet recruiting Advanced Solid Tumors SP-2577 Seclidemstat