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Schematic representation of the AML1–ETO (eight twenty one) repressor complex assembly. Transcriptional repression complex AML1/AML1-ETO recruits corepressors, including NCOR (nuclear receptor corepressor 1), HDACs (histone deacetylases), mSin3A (SIN3 transcription regulator family member A), and also interacts with DNMT1 (DNA methyltransferase 1) to promote DNA methylation and to repress target genes and miRNAs expression.
