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Wnt/β-catenin promotes spatial proximity and translocation of RUNX1 and RUNX1T1. Genomic structure of RUNX1 on chromosome 21 and RUNX1T1 on chromosome 8. Wnt/β-catenin was shown to induce spatial proximity and translocation of RUNX1 and RUNX1T1, which led to the generation of the RUNX1–RUNX1T1 fusion gene. Exons are depicted as boxes.
