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. 2019 Dec 7;11(12):1973. doi: 10.3390/cancers11121973

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© 2019 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of transcriptional repression mediated by CBFβ-SMMHC. For transcriptional repression, CBFβ-SMMHC retains the RUNX-binding domain in CBFβ and contains an additional RUNX-binding domain in the SMMHC. Fusion protein has the ability to interact specifically with mSin3A and HDAC8 (histone deacetylase 8) through an unexpected repression domain within the SMMHC portion. GATA2 (GATA binding protein 2); KLF1 (Kruppel-like factor 1); ID1 (inhibitor of DNA binding 1); LMO1 (LIM domain only 1); JAG1 (jagged canonical notch ligand 1).